Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 16/20 | 1.00 |
| ▸ | PKM | P14618 | 12/20 | 1.00 |
| ▸ | POLB | P06746 | 12/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 1.00 |
| ▸ | LMNA | P02545 | 10/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 1.00 |
| ▸ | ESR1 | P03372 | 5/20 | 1.00 |
| ▸ | RECQL | P46063 | 4/20 | 1.00 |
| ▸ | APEX1 | P27695 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 1.00 |
| ▸ | BLM | P54132 | 2/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 1.00 |
| ▸ | NR4A1 | P22736 | 1/20 | 1.00 |
| ▸ | CACNA1B | Q00975 | 1/20 | 1.00 |
| ▸ | APBA1 | Q02410 | 1/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.73 |
| ▸ | TSHR | P16473 | 7/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2017664 | 0.86 | ALDH1A1 (0.77) | ALDH1A1PKMPOLBSMN1; SMN2LMNA | |
| SCHEMBL2014912 | 0.85 | POLB (1.00) | ALDH1A1PKMPOLBSMN1; SMN2LMNA | |
| SCHEMBL10090671 | 0.83 | SMN1; SMN2 (0.72) | ALDH1A1PKMPOLBSMN1; SMN2LMNA | |
| SCHEMBL2016888 | 0.82 | POLB (0.84) | ALDH1A1PKMPOLBSMN1; SMN2LMNA | |
| SCHEMBL2016219 | 0.82 | SMN1; SMN2 (0.87) | ALDH1A1PKMPOLBSMN1; SMN2LMNA | |
| SCHEMBL2015501 | 0.82 | POLB (1.00) | ALDH1A1PKMPOLBSMN1; SMN2LMNA | |
| SCHEMBL2019581 | 0.82 | POLB (1.00) | ALDH1A1PKMPOLBSMN1; SMN2LMNA | |
| SCHEMBL2016416 | 0.81 | POLB (0.80) | ALDH1A1PKMPOLBSMN1; SMN2LMNA | |
| SCHEMBL2016203 | 0.81 | POLB (1.00) | ALDH1A1PKMPOLBSMN1; SMN2LMNA | |
| SCHEMBL2020480 | 0.81 | ALDH1A1 (1.00) | ALDH1A1PKMPOLBSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073929-A1 | 6-(2-FURYL)-3-METHYL-4-OXO-1,5,6,7-TETRAHYDROINDOLE-2-CARBOXYLATE DERIVATIVES AND USES THEREOF | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2011-06-23 | — | — | WO | claimed |
| WO-2023077077-A1 | RNA DEGRADERS AND USES THEREOF | ARRAKIS THERAPEUTICS, INC. (US) | 2023-05-04 | — | — | WO | disclosed |
| WO-2011073929-A1 | 6-(2-FURYL)-3-METHYL-4-OXO-1,5,6,7-TETRAHYDROINDOLE-2-CARBOXYLATE DERIVATIVES AND USES THEREOF | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011073929-A1 | 6-(2-FURYL)-3-METHYL-4-OXO-1,5,6,7-TETRAHYDROINDOLE-2-CARBOXYLATE DERIVATIVES AND USES THEREOF | ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (IT) | 2011-06-23 | — | — | WO | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | BCL2, BAX, BAD | ALDH1A1 3724/4885PKM 4036/4885POLB 1539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.