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SCHEMBL20158446

SCHEMBL20158446

CC(NC(=O)OC(C)(C)C)C(=O)NC1(C)CCN(C(C)C)CC1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.40
▸ CTSL P07711 4/20 0.39
▸ GLS O94925 1/20 0.37
▸ HRH3 Q9Y5N1 1/20 0.36
▸ CA1 P00915 1/20 0.35
▸ CA2 P00918 1/20 0.35
▸ CA7 P43166 1/20 0.35
▸ PREP P48147 1/20 0.35
▸ CTSK P43235 3/20 0.34
▸ CTSB P07858 2/20 0.34
▸ FDPS P14324 1/20 0.34
▸ CTSS P25774 2/20 0.34
▸ GLA P06280 1/20 0.34
▸ HRH2 P25021 2/20 0.34
▸ HRH1 P35367 2/20 0.34
▸ MEN1 O00255 1/20 0.33
▸ CYP2D6 P10635 1/20 0.33
▸ RET P07949 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18705060 0.86 HRH3 (0.40) KMT2ACTSLHRH3CA1CA2
SCHEMBL20069550 0.85 CTSK (0.47) CTSLCA1CA2CA7CTSK
SCHEMBL20205766 0.79 RET (0.39) CTSLHRH3CA1CA2CA7
SCHEMBL20148046 0.77 RET (0.34) HRH3CYP2D6RET
SCHEMBL20070300 0.77 RET (0.40) CTSLHRH3CTSKCTSBRET
SCHEMBL20070400 0.77 RET (0.40) CTSLHRH3CTSKCTSBRET
SCHEMBL20068884 0.77 RET (0.43) HRH3RET
SCHEMBL20206055 0.75 CTSL (0.34) KMT2ACTSLHRH3CA1CA2
SCHEMBL18705063 0.75 MMP9 (0.33) HRH3CYP2D6RET
SCHEMBL20158550 0.74 RET (0.42) CTSLHRH3CTSKCTSBCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11648243-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2023-05-16 — — US disclosed
US-11648243-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2023-05-16 — — US disclosed
US-10172845-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors ARRAY BIOPHARMA INC. (US) 2019-01-08 — — US disclosed
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-31 — — US disclosed
US-20180134703-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS ARRAY BIOPHARMA INC. 2018-05-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180148445-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 KMT2A 1112/4885CTSL 4508/4885GLS 2655/4885
US-11648243-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 KMT2A 1112/4885CTSL 4508/4885GLS 2655/4885
US-10172845-B2 Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors RET, BRAF, RAF1 KMT2A 1112/4885CTSL 4508/4885GLS 2655/4885
US-20180134703-A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS RET, BRAF, RAF1 KMT2A 1112/4885CTSL 4508/4885GLS 2655/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.