Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159747 | 0.89 | GSK3B (0.40) | MEN1GAAKMT2ACYP1A2CYP2C9 | |
| SCHEMBL20138842 | 0.81 | PDE4B (0.40) | MEN1GAAKMT2ALMNASMN1; SMN2 | |
| SCHEMBL20159539 | 0.79 | HRH3 (0.36) | CYP1A2CYP2C19 | |
| SCHEMBL20138839 | 0.79 | CYP19A1 (0.39) | MEN1KMT2ALMNASMN1; SMN2NPC1 | |
| SCHEMBL20159716 | 0.79 | PDE4B (0.36) | MEN1KMT2ALMNASMN1; SMN2NPC1 | |
| SCHEMBL20159528 | 0.77 | PDE4B (0.40) | MEN1KMT2ACYP2C9 | |
| SCHEMBL20159426 | 0.76 | CYP19A1 (0.38) | MEN1KMT2A | |
| SCHEMBL20159516 | 0.75 | PDE4B (0.34) | MEN1KMT2A | |
| SCHEMBL20159396 | 0.75 | HRH3 (0.36) | MEN1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20142920 | 0.75 | CYP19A1 (0.45) | MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021013693-A1 | ANTIBODY DRUG CONJUGATES (ADCS) WITH NAMPT INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2021-01-28 | — | — | WO | disclosed |
| WO-2018086703-A1 | DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2018-05-17 | — | — | WO | disclosed |