Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20158920 | 0.86 | MTOR (0.51) | MTORRPTORMLST8SMN1; SMN2MAPT | |
| SCHEMBL20159285 | 0.86 | MTOR (0.51) | MTORRPTORMLST8SMN1; SMN2MAPT | |
| SCHEMBL20140500 | 0.80 | MTOR (0.67) | MTORRPTORMLST8SMN1; SMN2MAPK1 | |
| SCHEMBL20159289 | 0.78 | MTOR (0.63) | MTORRPTORMLST8SMN1; SMN2MAPK1 | |
| SCHEMBL20140534 | 0.78 | MTOR (0.63) | MTORRPTORMLST8SMN1; SMN2MAPK1 | |
| SCHEMBL20139786 | 0.75 | MTOR (0.51) | MTORRPTORMLST8SMN1; SMN2MEN1 | |
| SCHEMBL20159115 | 0.73 | MTOR (0.55) | MTORRPTORMLST8SMN1; SMN2MAPK1 | |
| SCHEMBL20140543 | 0.73 | MTOR (0.65) | MTORRPTORMLST8SMN1; SMN2MEN1 | |
| SCHEMBL20140555 | 0.72 | MTOR (0.78) | MTORRPTORMLST8HTTMEN1 | |
| SCHEMBL20139283 | 0.72 | MTOR (0.63) | MTORRPTORMLST8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |