Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.51 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.51 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20159024 | 0.79 | MTOR (0.64) | MTORRPTORMLST8POLBKMT2A | |
| SCHEMBL20159282 | 0.75 | MTOR (0.48) | MTORRPTORMLST8KMT2AMEN1 | |
| SCHEMBL20140717 | 0.73 | KMT2A (0.49) | MTORRPTORMLST8POLBKMT2A | |
| SCHEMBL20159115 | 0.72 | MTOR (0.55) | MTORRPTORMLST8POLBSMN1; SMN2 | |
| SCHEMBL20140555 | 0.71 | MTOR (0.78) | MTORRPTORMLST8POLBKMT2A | |
| SCHEMBL20159302 | 0.70 | TP53 (0.53) | POLBKMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL20139683 | 0.70 | KMT2A (0.51) | POLBKMT2AMEN1THRBLMNA | |
| SCHEMBL20158902 | 0.70 | MTOR (0.57) | MTORRPTORMLST8KMT2AMEN1 | |
| SCHEMBL20159018 | 0.69 | MTOR (0.59) | MTORRPTORMLST8SMN1; SMN2DRD2 | |
| SCHEMBL20159079 | 0.69 | MTOR (0.52) | MTORRPTORMLST8POLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |
| WO-2018089493-A1 | PYRROLE mTORC INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-05-17 | — | — | WO | disclosed |