Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 9/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | RHEB | Q15382 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20142944 | 0.85 | AR (0.33) | ARCDK8RHEBESR1MGLL | |
| SCHEMBL23504842 | 0.81 | LMNA (0.39) | CDK8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL23504812 | 0.78 | CDK1 (0.35) | — | |
| SCHEMBL23504771 | 0.78 | HTR2A (0.41) | — | |
| SCHEMBL20159299 | 0.73 | HTR2A (0.37) | ARCDK8MGLLABL1SRC | |
| SCHEMBL20159274 | 0.73 | HTR2A (0.37) | ARMGLLPSEN1PSEN2APH1B | |
| SCHEMBL20159329 | 0.72 | PLA2G7 (0.40) | — | |
| SCHEMBL29623386 | 0.72 | PLA2G7 (0.40) | — | |
| SCHEMBL20138679 | 0.71 | AR (0.32) | ARMGLLS1PR1 | |
| SCHEMBL20159726 | 0.71 | KCNH2 (0.39) | ARCDK8MGLLKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087018-A1 | PHENOXYTRIAZOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-17 | — | — | WO | disclosed |