Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21569649 | 0.87 | JAK2 (0.50) | ALDH1A1USP2MEN1TSHRKMT2A | |
| SCHEMBL8442356 | 0.85 | KDM4E (0.68) | ALDH1A1KDM4EKMT2AOPRM1SIGMAR1 | |
| SCHEMBL785972 | 0.83 | JAK2 (0.54) | ALDH1A1KDM4EMEN1KMT2AOPRM1 | |
| SCHEMBL7280301 | 0.81 | LTA4H (0.63) | ALDH1A1KDM4EMEN1KMT2AOPRM1 | |
| SCHEMBL20871938 | 0.80 | KDM4E (0.62) | ALDH1A1KDM4EKMT2AOPRM1SIGMAR1 | |
| SCHEMBL13588401 | 0.79 | ALDH1A1 (0.73) | ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL14487965 | 0.78 | LTA4H (0.54) | ALDH1A1KDM4EOPRM1SIGMAR1LTA4H | |
| SCHEMBL18424508 | 0.78 | KMT2A (0.56) | MEN1KMT2AOPRM1SIGMAR1JAK2 | |
| SCHEMBL26617983 | 0.77 | KDM4E (0.57) | ALDH1A1KDM4EKMT2AOPRM1SIGMAR1 | |
| SCHEMBL14144125 | 0.77 | JAK2 (0.52) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089695-A1 | TOLL-LIKE RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USE | DYNAVAX TECHNOLOGIES CORPORATION (US) | 2018-05-17 | — | — | WO | disclosed |