Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.52 |
| ▸ | RORC | P51449 | 3/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | UBE2M | P61081 | 1/20 | 0.46 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26618018 | 0.92 | KMT2A (0.55) | LTA4HJAK2JAK1AGTR2RORC | |
| SCHEMBL785972 | 0.90 | JAK2 (0.54) | LTA4HJAK2JAK1AGTR2OPRM1 | |
| SCHEMBL9451691 | 0.86 | LTA4H (0.57) | LTA4HRORCOPRM1KDM4E | |
| Hydrochloric Acid SCHEMBL7468874 | 0.85 | CHIA (0.50) | LTA4HAGTR2OPRM1SIGMAR1NPY5R | |
| SCHEMBL18424508 | 0.84 | KMT2A (0.56) | LTA4HJAK2JAK1AGTR2OPRM1 | |
| SCHEMBL14144125 | 0.83 | JAK2 (0.52) | LTA4HJAK2JAK1AGTR2OPRM1 | |
| SCHEMBL803527 | 0.81 | JAK2 (0.74) | JAK2JAK1KMT2AKDM4EMEN1 | |
| SCHEMBL20160113 | 0.81 | ALDH1A1 (0.56) | LTA4HJAK2JAK1AGTR2OPRM1 | |
| SCHEMBL16757240 | 0.81 | KMT2A (0.69) | RORCOPRM1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7292853 | 0.80 | L3MBTL3 (0.55) | LTA4HJAK2JAK1AGTR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457686-B1 | Novel aminopiperidine, aminopyrrolidine and aminoperhydroazepine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1994-08-03 | — | — | EP | disclosed |
| US-5214055-A | Analgesics, psychological disorders, anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1993-05-25 | — | — | US | disclosed |
| US-5189045-A | Antiserotonine agent | ADIR ET COMPAGNIE (FR) | 1993-02-23 | — | — | US | disclosed |
| EP-0457686-A1 | Novel aminopiperidine, aminopyrrolidine and aminoperhydroazepine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-11-21 | — | — | EP | disclosed |