Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | QDPR | P09417 | 2/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13490629 | 0.84 | CCR1 (0.48) | SLC6A4QDPRWNT3A | |
| SCHEMBL13490635 | 0.81 | QDPR (0.45) | QDPRWNT3A | |
| SCHEMBL21038282 | 0.81 | SLC6A4 (0.46) | SLC6A4QDPRWNT3A | |
| SCHEMBL13490631 | 0.81 | NAMPT (0.34) | — | |
| SCHEMBL16283731 | 0.79 | QDPR (0.43) | QDPRWNT3A | |
| SCHEMBL13490628 | 0.79 | WNT3A (0.47) | QDPRWNT3A | |
| SCHEMBL21614488 | 0.79 | QDPR (0.45) | SLC6A4QDPR | |
| SCHEMBL979985 | 0.79 | WNT3A (0.46) | WNT3A | |
| SCHEMBL18372250 | 0.79 | NAMPT (0.33) | WNT3A | |
| SCHEMBL13591401 | 0.78 | QDPR (0.49) | QDPRWNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12162879-B2 | Pyridopyrimidine derivative, preparation method therefor and medical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2024-12-10 | — | — | US | disclosed |
| CN-115710266-B | Pyridopyrimidine derivative, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2024-09-13 | — | — | CN | disclosed |
| CN-115362155-B | Arylamine derivative, preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2024-06-18 | — | — | CN | disclosed |
| CN-115710266-A | Pyridopyrimidine derivative, preparation method thereof and application thereof in medicines | 江苏恒瑞医药股份有限公司 | 2023-02-24 | — | — | CN | disclosed |
| CN-111094289-B | Pyridopyrimidine derivative, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-115362155-A | Arylamine derivatives, and preparation method and medical application thereof | 中国医药研究开发中心有限公司 | 2022-11-18 | — | — | CN | disclosed |
| EP-3822271-A1 | PYRIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2021-05-19 | — | — | EP | disclosed |
| WO-2020007275-A1 | PYRIDOPYRIMIDINE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2020-01-09 | — | — | WO | disclosed |
| WO-2018086589-A1 | 1,5,7-TRI-SUBSTITUTED ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES | 上海海雁医药科技有限公司 | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12162879-B2 | Pyridopyrimidine derivative, preparation method therefor and medical use thereof | TLR8, TLR7, TLR1 | SLC6A4 1928/4885QDPR 414/4885WNT3A 2566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.