Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22143526 | 1.00 | DUSP3 (0.34) | DUSP3KDM4EATML3MBTL1KMT2A | |
| SCHEMBL22143422 | 1.00 | DUSP3 (0.34) | DUSP3KDM4EATML3MBTL1KMT2A | |
| SCHEMBL18505602 | 0.92 | DUSP3 (0.34) | DUSP3KDM4EATML3MBTL1KMT2A | |
| SCHEMBL14681681 | 0.91 | KDM4E (0.35) | DUSP3KDM4EATML3MBTL1KMT2A | |
| SCHEMBL17034667 | 0.89 | L3MBTL1 (0.39) | DUSP3KDM4EATML3MBTL1KMT2A | |
| SCHEMBL20161202 | 0.88 | MDM2 (0.37) | DUSP3KDM4EATML3MBTL1KMT2A | |
| SCHEMBL20160997 | 0.88 | MDM2 (0.37) | DUSP3KDM4EATML3MBTL1KMT2A | |
| SCHEMBL20161201 | 0.88 | MDM2 (0.37) | DUSP3KDM4EATML3MBTL1KMT2A | |
| SCHEMBL2603525 | 0.88 | DUSP3 (0.37) | DUSP3KDM4EATML3MBTL1 | |
| SCHEMBL17379733 | 0.87 | KDM4E (0.32) | KDM4EATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230354701-A1 | COMPOUNDS WITH AN ACCEPTOR AND A DONOR GROUP | MERCK PATENT GMBH (DE) | 2023-11-02 | — | — | US | disclosed |
| US-20230354701-A1 | COMPOUNDS WITH AN ACCEPTOR AND A DONOR GROUP | MERCK PATENT GMBH (DE) | 2023-11-02 | — | — | US | disclosed |
| US-11711976-B2 | Compounds with an acceptor and a donor group | MERCK PATENT GMBH (DE) | 2023-07-25 | — | — | US | disclosed |
| US-11711976-B2 | Compounds with an acceptor and a donor group | MERCK PATENT GMBH (DE) | 2023-07-25 | — | — | US | disclosed |
| US-20200203624-A1 | COMPOUNDS WITH AN ACCEPTOR AND A DONOR GROUP | MERCK PATENT GMBH (DE) | 2020-06-25 | — | — | US | disclosed |
| WO-2018087346-A1 | COMPOUNDS WITH AN ACCEPTOR AND A DONOR GROUP | MERCK PATENT GMBH (DE) | 2018-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11711976-B2 | Compounds with an acceptor and a donor group | NQO1, ICMT, NUDT1 | DUSP3 4229/4885KDM4E 2457/4885ATM 3290/4885 |
| US-20200203624-A1 | COMPOUNDS WITH AN ACCEPTOR AND A DONOR GROUP | NQO1, ICMT, NUDT1 | DUSP3 4229/4885KDM4E 2457/4885ATM 3290/4885 |
| US-20230354701-A1 | COMPOUNDS WITH AN ACCEPTOR AND A DONOR GROUP | NQO1, ICMT, NUDT1 | DUSP3 4229/4885KDM4E 2457/4885ATM 3290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.