Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 4/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | CAMKK1 | Q8N5S9 | 2/20 | 0.40 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.39 |
| ▸ | CMKLR1 | Q99788 | 2/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.37 |
| ▸ | EPRS1 | P07814 | 1/20 | 0.37 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12499397 | 0.87 | CMKLR1 (0.39) | PDE9AESR1CMKLR1EZH1EZH2 | |
| SCHEMBL12499686 | 0.82 | S1PR1 (0.43) | PDE9ACMKLR1EZH1 | |
| SCHEMBL2591384 | 0.78 | PDE9A (0.43) | PDE9ACAMKK1CAMKK2KDM5AKDM4C | |
| SCHEMBL2594585 | 0.78 | OPRK1 (0.43) | PDE9AKDM5AKDM4CKDM5BHCAR3 | |
| SCHEMBL2594124 | 0.77 | KDM4E (0.48) | PDE9ACAMKK1CAMKK2KDM5AKDM4C | |
| SCHEMBL19371874 | 0.75 | DHODH (0.38) | CAPN1CAMKK1CAMKK2POLBKDM4E | |
| SCHEMBL12499844 | 0.75 | CMKLR1 (0.41) | PDE9ACMKLR1KDM4E | |
| SCHEMBL12499801 | 0.75 | S1PR1 (0.46) | PDE9ADHODH | |
| SCHEMBL12498440 | 0.75 | KDM5A (0.41) | PDE9AKDM5AKDM4CKDM5BHCAR3 | |
| SCHEMBL3465105 | 0.74 | KDM4E (0.42) | PDE9AKDM5AKDM4CKDM5BHCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323820-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |