Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL862637 | 0.82 | ALDH1A1 (0.37) | MAPTMEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL1817115 | 0.81 | MAPT (0.36) | MAPTMEN1KMT2AHSD17B10ALOX12 | |
| SCHEMBL19942280 | 0.81 | MAPT (0.38) | MAPTMEN1KMT2AHSD17B10ALOX12 | |
| SCHEMBL16361670 | 0.81 | SNCA (0.41) | MAPTMEN1KMT2AHSD17B10ALOX12 | |
| SCHEMBL14052845 | 0.81 | MAPT (0.43) | MAPTMEN1KMT2AHSD17B10ALOX12 | |
| SCHEMBL21772851 | 0.80 | RXFP1 (0.40) | MAPTMEN1KMT2AHSD17B10ALOX12 | |
| SCHEMBL14123527 | 0.79 | MAPT (0.34) | MAPTMEN1KMT2AHSD17B10ALOX12 | |
| SCHEMBL14461141 | 0.78 | MCHR1 (0.34) | — | |
| SCHEMBL17791437 | 0.78 | MCHR1 (0.34) | — | |
| SCHEMBL13832869 | 0.77 | POLB (0.33) | MAPTMEN1KMT2AHSD17B10ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107580622-B | Thiadiazole quinoxaline derivative | 默克专利股份有限公司 | 2021-03-23 | — | — | CN | disclosed |
| US-10738240-B2 | Thiadiazoloquinoxaline derivatives | MERCK PATENT GMBH (DE) | 2020-08-11 | — | — | US | disclosed |
| US-20180142153-A1 | THIADIAZOLOQUINOXALINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-05-24 | — | — | US | disclosed |