Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 7/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 6/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.46 |
| ▸ | PIM1 | P11309 | 5/20 | 0.46 |
| ▸ | PRKACA | P17612 | 5/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.46 |
| ▸ | GSK3A | P49840 | 5/20 | 0.46 |
| ▸ | GSK3B | P49841 | 5/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 4/20 | 0.46 |
| ▸ | FLT1 | P17948 | 4/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592815 | 0.84 | GPR35 (0.42) | DAPK3ROCK1PIM1PRKACAGSK3A | |
| Hydrochloric Acid SCHEMBL5981436 | 0.82 | GPR35 (0.41) | DAPK3ROCK1PIM1PRKACAGSK3A | |
| SCHEMBL6202717 | 0.71 | PIM1 (0.46) | KDRDAPK3ROCK1CHEK1CDK5 | |
| SCHEMBL4073478 | 0.68 | PDPK1 (0.39) | KDRDAPK3ROCK1CHEK1CDK5 | |
| SCHEMBL24163133 | 0.67 | — | — | |
| SCHEMBL21167345 | 0.67 | — | — | |
| SCHEMBL15514276 | 0.66 | CSNK2A2 (0.58) | KDRCHEK1CDK8CSNK2A1CSNK2A2 | |
| SCHEMBL2016376 | 0.64 | KDR (0.49) | KDRDAPK3ROCK1CHEK1CDK5 | |
| SCHEMBL30250552 | 0.64 | GDA (0.43) | KDRDAPK3ROCK1CHEK1CDK5 | |
| SCHEMBL8272426 | 0.64 | RPS6KB1 (0.39) | CHEK1PDPK1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108368057-B | Pyrazolo-fused heterocyclic compounds as ERK inhibitors | 捷思英达医药技术（上海）有限公司 | 2022-03-15 | — | — | CN | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| EP-2121626-A1 | BENZIMIDAZOLE DERIVATIVES | Pfizer Products Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| EP-2007380-A2 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-31 | — | — | EP | claimed |
| WO-2008075196-A1 | BENZIMIDAZOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2008-06-26 | — | — | WO | claimed |
| WO-2007113198-A2 | USE OF A KINASE INHIBITOR FOR THE TREATMENT OF PARTICULAR RESISTANT TUMORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-10-11 | — | — | WO | claimed |
| EP-1711177-A1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | Pfizer Italia S.r.l. (IT) | 2006-10-18 | — | — | EP | claimed |
| WO-2005074922-A1 | 1H-THIENO[2,3-c]PYRAZOLE DERIVATIVES USEFUL AS KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2005-08-18 | — | — | WO | claimed |
| WO-2025042956-A1 | PDE 7 MODULATOR COMPOUNDS | OMEROS CORPORATION (US) | 2025-02-27 | — | — | WO | disclosed |
| EP-3806888-B1 | PDE5 DERIVED REGULATORY CONSTRUCTS AND METHODS OF USE IN IMMUNOTHERAPY | OBSIDIAN THERAPEUTICS INC (US) | 2024-01-31 | — | — | EP | disclosed |
| US-11666642-B2 | PDE5 compositions and methods for immunotherapy | OBSIDIAN THERAPEUTICS, INC. (US) | 2023-06-06 | — | — | US | disclosed |
| US-20230074330-A1 | PDE5 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY | OBSIDIAN THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | US | disclosed |
| US-20220403001-A1 | PDE5 DERIVED REGULATORY CONSTRUCTS AND METHODS OF USE IN IMMUNOTHERAPY | OBSIDIAN THERAPEUTICS, INC. (US) | 2022-12-22 | — | — | US | disclosed |
| CN-108368057-B | Pyrazolo-fused heterocyclic compounds as ERK inhibitors | 捷思英达医药技术（上海）有限公司 | 2022-03-15 | — | — | CN | disclosed |
| WO-2006092510-A1 | HYDRAZINOCARBONYL-THIENO[2,3-C]PYRAZOLES, PREPARATION METHOD, COMPOSITIONS CONTAINING SAME AND USE | AVENTIS PHARMA S.A. (FR) | 2006-09-08 | — | — | WO | disclosed |
| WO-2005074922-A1 | 1H-THIENO[2,3-c]PYRAZOLE DERIVATIVES USEFUL AS KINASE INHIBITORS | PFIZER ITALIA S.R.L. (IT) | 2005-08-18 | — | — | WO | disclosed |
| EP-1534716-A1 | HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2005-06-01 | — | — | EP | disclosed |
| EP-1530573-A1 | CONDENSED HETEROCYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2005-05-18 | — | — | EP | disclosed |
| WO-2004013146-A1 | CONDENSED HETEROCYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A (IT) | 2004-02-12 | — | — | WO | disclosed |
| WO-2004007504-A1 | HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2004-01-22 | — | — | WO | disclosed |