Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 7/20 | 0.46 |
| ▸ | GSK3A | P49840 | 7/20 | 0.46 |
| ▸ | GSK3B | P49841 | 7/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.46 |
| ▸ | KDR | P35968 | 6/20 | 0.46 |
| ▸ | PRKACA | P17612 | 6/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 5/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 4/20 | 0.46 |
| ▸ | CLK2 | P49760 | 4/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 4/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.46 |
| ▸ | FLT1 | P17948 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205077 | 0.84 | GPR35 (0.42) | PIM1GSK3AGSK3BKDRPRKACA | |
| SCHEMBL12489469 | 0.82 | CLK1 (0.41) | PIM1GSK3BDYRK1AROCK1CDK8 | |
| SCHEMBL12489731 | 0.78 | CSNK2A2 (0.47) | GSK3AGSK3BKDRDYRK1AAURKB | |
| SCHEMBL12489594 | 0.73 | CLK1 (0.50) | DYRK1AROCK1CLK2CDK8DYRK1B | |
| SCHEMBL2016377 | 0.71 | KDR (0.46) | PIM1GSK3AGSK3BCDK5KDR | |
| SCHEMBL3260658 | 0.69 | KDR (0.44) | PIM1GSK3AGSK3BCDK5KDR | |
| SCHEMBL1622149 | 0.67 | CYP2A6 (0.40) | PIM1GSK3AGSK3BCDK5KDR | |
| Hydrochloric Acid SCHEMBL2175969 | 0.66 | CYP2A6 (0.42) | ROCK1CHEK1ROCK2 | |
| SCHEMBL6202716 | 0.64 | ICAM1 (0.45) | PIM1GSK3AGSK3BCDK5KDR | |
| SCHEMBL2178433 | 0.64 | CHEK1 (0.32) | ROCK1CHEK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534716-A1 | HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004007504-A1 | HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2004-01-22 | — | — | WO | disclosed |