Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.52 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.52 |
| ▸ | LTA4H | P09960 | 9/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.45 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17201789 | 1.00 | SPHK1 (0.52) | SPHK1SPHK2LTA4HS1PR1S1PR3 | |
| SCHEMBL14956872 | 1.00 | SPHK1 (0.52) | SPHK1SPHK2LTA4HS1PR1S1PR3 | |
| SCHEMBL23125177 | 0.83 | LTA4H (0.62) | SPHK1SPHK2LTA4HS1PR1S1PR3 | |
| SCHEMBL17661962 | 0.83 | LTA4H (0.56) | SPHK1SPHK2LTA4HS1PR1S1PR3 | |
| SCHEMBL23125175 | 0.83 | LTA4H (0.62) | SPHK1SPHK2LTA4HS1PR1S1PR3 | |
| SCHEMBL17637516 | 0.83 | LTA4H (0.56) | SPHK1SPHK2LTA4HS1PR1S1PR3 | |
| SCHEMBL19375764 | 0.83 | SPHK1 (0.49) | SPHK1SPHK2LTA4HS1PR1S1PR3 | |
| SCHEMBL26266218 | 0.82 | SPHK1 (0.68) | SPHK1SPHK2S1PR1S1PR3S1PR4 | |
| SCHEMBL13258710 | 0.82 | LTA4H (0.62) | SPHK1SPHK2LTA4HS1PR1S1PR3 | |
| SCHEMBL17801791 | 0.81 | SPHK1 (0.51) | SPHK1SPHK2LTA4HS1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210205463-A1 | STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES | PFIZER INC. (US) | 2021-07-08 | — | — | US | disclosed |
| US-10967068-B2 | Stability-modulating linkers for use with antibody drug conjugates | PFIZER INC. (US) | 2021-04-06 | — | — | US | disclosed |
| EP-3185908-B1 | STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES | PFIZER (US) | 2020-04-15 | — | — | EP | disclosed |
| US-20180140714-A1 | STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES | PFIZER INC. (US) | 2018-05-24 | — | — | US | disclosed |
| CN-107660208-A | Bifunctional cytotoxic agents comprising a CTI pharmacophore | 辉瑞公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-106795203-A | Stability for antibody drug conjugate adjusts joint | 辉瑞公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-104185477-A | Cytotoxic peptides and antibody-drug conjugates thereof | PFIZER | 2014-12-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10967068-B2 | Stability-modulating linkers for use with antibody drug conjugates | FCGR2A, FCGRT, FCGR1A | SPHK1 2797/4885SPHK2 2435/4885LTA4H 3135/4885 |
| US-20210205463-A1 | STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES | FCGR2A, FCGRT, FCGR1A | SPHK1 2797/4885SPHK2 2435/4885LTA4H 3135/4885 |
| US-20180140714-A1 | STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES | FCGR2A, FCGRT, FCGR1A | SPHK1 2797/4885SPHK2 2435/4885LTA4H 3135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.