SCHEMBL20164431

SCHEMBL20164431

CNc1nc(Cl)nc2c(NCCO)nc(Cl)nc12

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SLC29A1 Q99808 5/20 0.46
HTT P42858 1/20 0.46
YTHDC1 Q96MU7 7/20 0.45
KMT2A Q03164 2/20 0.41
POLB P06746 1/20 0.38
KDM4E B2RXH2 1/20 0.38
MAPK1 P28482 1/20 0.38
IKBKB O14920 1/20 0.37
YTHDF3 Q7Z739 2/20 0.36
YTHDF1 Q9BYJ9 2/20 0.36
YTHDF2 Q9Y5A9 2/20 0.36
MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20164757 0.88 SLC29A1 (0.54) SLC29A1HTTYTHDC1KMT2AMAPK1
SCHEMBL20164638 0.86 SLC29A1 (0.54) SLC29A1HTTKMT2APOLBKDM4E
SCHEMBL20164652 0.84 SLC29A1 (0.44) SLC29A1HTTKMT2APOLBKDM4E
SCHEMBL20164700 0.81 HTT (0.49) SLC29A1HTTKMT2APOLBKDM4E
SCHEMBL20164636 0.81 SLC29A1 (0.43) SLC29A1HTTKMT2APOLBKDM4E
SCHEMBL16094334 0.80 YTHDC1 (0.61) YTHDC1YTHDF3YTHDF1YTHDF2
SCHEMBL20164763 0.80 SLC29A1 (0.60) SLC29A1HTTKMT2APOLBKDM4E
Hydrochloric Acid SCHEMBL20164519 0.79 SLC29A1 (0.58) SLC29A1HTTKMT2APOLBKDM4E
SCHEMBL20164550 0.78 HTT (0.40) SLC29A1HTTKMT2APOLBKDM4E
SCHEMBL20164352 0.78 HTT (0.40) SLC29A1HTTKMT2APOLBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3316890-B1 NOVEL BREATHING CONTROL MODULATING COMPOUNDS, AND METHODS OF MAKING AND USING SAME NEURAD LTD (IL) 2023-09-06 EP disclosed
US-10294228-B2 Breathing control modulating compounds, and methods of making and using same NEURAD LTD. (IL) 2019-05-21 US disclosed
US-20180141953-A1 Novel Breathing Control Modulating Compounds, and Methods of Making and Using Same NEURAD LTD. (IL) 2018-05-24 US disclosed
CN-107708701-A Novel respiratory control modulating compounds and methods of making and using the same 纽拉德有限公司 2018-02-16 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180141953-A1 Novel Breathing Control Modulating Compounds, and Methods of Making and Using Same MTNR1B, CHRM3, PER2 SLC29A1 4472/4885HTT 1972/4885YTHDC1 2024/4885
US-10294228-B2 Breathing control modulating compounds, and methods of making and using same MTNR1B, PDE3A, CHRM3 SLC29A1 4518/4885HTT 1791/4885YTHDC1 2085/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.