Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ACSS2 | Q9NR19 | 5/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.39 |
| ▸ | SCNN1A | P37088 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018430 | 0.93 | ACSS2 (0.42) | HTTACSS2SCNN1AKCNH2 | |
| SCHEMBL2022069 | 0.92 | ACSS2 (0.47) | HTTACSS2SCNN1ACTSAKCNH2 | |
| SCHEMBL2018438 | 0.92 | SCNN1A (0.44) | HTTACSS2MTNR1AMTNR1BSCNN1A | |
| SCHEMBL12635701 | 0.91 | ACSS2 (0.49) | HTTACSS2MTNR1AMTNR1BSCNN1A | |
| SCHEMBL12635952 | 0.90 | HTT (0.41) | HTTACSS2MTNR1AMTNR1BSCNN1A | |
| SCHEMBL2015793 | 0.90 | KCNH2 (0.49) | HTTACSS2SCNN1AKDM4EKCNH2 | |
| SCHEMBL16882065 | 0.89 | SCNN1A (0.40) | HTTACSS2SCNN1AKCNH2 | |
| SCHEMBL2017976 | 0.88 | HTT (0.40) | HTTACSS2SCNN1ACTSAKCNH2 | |
| SCHEMBL21335806 | 0.88 | SCNN1A (0.39) | HTTACSS2SCNN1AKCNH2 | |
| SCHEMBL2040435 | 0.88 | HTT (0.45) | HTTACSS2CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |