Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | ACSS2 | Q9NR19 | 7/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | SCNN1A | P37088 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016536 | 0.90 | HTT (0.42) | KCNH2ACSS2HTTKDM4ESCNN1A | |
| SCHEMBL2022069 | 0.89 | ACSS2 (0.47) | KCNH2ACSS2HTTSCNN1AMEN1 | |
| SCHEMBL2018430 | 0.88 | ACSS2 (0.42) | KCNH2ACSS2HTTSCNN1AS1PR3 | |
| SCHEMBL2018438 | 0.87 | SCNN1A (0.44) | ACSS2HTTSCNN1AMAPT | |
| SCHEMBL12635701 | 0.86 | ACSS2 (0.49) | KCNH2ACSS2HTTSCNN1A | |
| SCHEMBL2017976 | 0.85 | HTT (0.40) | KCNH2ACSS2HTTSCNN1AMEN1 | |
| SCHEMBL12635952 | 0.85 | HTT (0.41) | KCNH2ACSS2HTTALDH1A1GLA | |
| SCHEMBL2014823 | 0.84 | HTT (0.45) | HTTHSD17B10SCNN1ACYP1A2CYP2D6 | |
| SCHEMBL21335806 | 0.83 | SCNN1A (0.39) | KCNH2ACSS2HTTSCNN1A | |
| SCHEMBL2040435 | 0.83 | HTT (0.45) | ACSS2HTTALDH1A1GLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |