SCHEMBL20165417

SCHEMBL20165417

C/C=C\c1ccccc1OCC(=O)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 4/20 0.55
TDP1 Q9NUW8 3/20 0.55
MEN1 O00255 6/20 0.53
KMT2A Q03164 6/20 0.53
ALDH1A1 P00352 2/20 0.51
PTGDR2 Q9Y5Y4 1/20 0.50
LMNA P02545 6/20 0.49
MAPK1 P28482 3/20 0.49
MAPT P10636 7/20 0.47
NPSR1 Q6W5P4 4/20 0.47
RAB9A P51151 5/20 0.47
NPC1 O15118 4/20 0.47
BCHE P06276 1/20 0.47
ROCK2 O75116 1/20 0.46
TNKS O95271 1/20 0.46
PARP1 P09874 1/20 0.46
ROCK1 Q13464 1/20 0.46
PARP14 Q460N5 1/20 0.46
PARP10 Q53GL7 1/20 0.46
PARP2 Q9UGN5 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20165421 1.00 L3MBTL1 (0.55) L3MBTL1TDP1MEN1KMT2AALDH1A1
SCHEMBL2342765 0.86 PTGDR2 (0.68) L3MBTL1TDP1MEN1KMT2AALDH1A1
SCHEMBL2317111 0.83 KMT2A (0.53) L3MBTL1TDP1MEN1KMT2AALDH1A1
SCHEMBL2601637 0.83 KMT2A (0.53) L3MBTL1TDP1MEN1KMT2AALDH1A1
SCHEMBL1382747 0.83 PTGDR2 (0.73) L3MBTL1TDP1MEN1KMT2AALDH1A1
SCHEMBL3312018 0.80 MEN1 (0.51) L3MBTL1MEN1KMT2AALDH1A1PTGDR2
SCHEMBL9787048 0.80 L3MBTL1 (0.73) L3MBTL1TDP1MEN1KMT2AALDH1A1
SCHEMBL16382639 0.77 MEN1 (0.48) L3MBTL1MEN1KMT2AALDH1A1PTGDR2
SCHEMBL9787058 0.76 L3MBTL1 (0.71) L3MBTL1TDP1MEN1KMT2AALDH1A1
SCHEMBL2398594 0.76 MAPT (0.67) L3MBTL1TDP1MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109982993-B Asymmetrically substituted dienyl diphenyl ethers, their preparation and use 赢创运营有限公司 2022-06-07 CN disclosed
EP-3541773-B1 ASYMMETRICALLY SUBSTITUTED BIS-ALKENYL DIPHENYL ETHERS, THEIR PREPARATION AND USE EVONIK OPERATIONS GMBH (DE) 2020-05-13 EP disclosed
US-20190367652-A1 ASYMMETRICALLY SUBSTITUTED BIS-ALKENYL DIPHENYL ETHERS, THEIR PREPARATION AND USE EVONIK TECHNOCHEMIE GMBH (DE) 2019-12-05 US disclosed
EP-3541773-A1 ASYMMETRICALLY SUBSTITUTED BIS-ALKENYL DIPHENYL ETHERS, THEIR PREPARATION AND USE Evonik Technochemie GmbH (DE) 2019-09-25 EP disclosed
WO-2018091253-A1 ASYMMETRICALLY SUBSTITUTED BIS-ALKENYL DIPHENYL ETHERS, THEIR PREPARATION AND USE EVONIK TECHNOCHEMIE GMBH (DE) 2018-05-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190367652-A1 ASYMMETRICALLY SUBSTITUTED BIS-ALKENYL DIPHENYL ETHERS, THEIR PREPARATION AND USE ITGB3, C9, CBR3 L3MBTL1 1744/4885TDP1 3692/4885MEN1 3075/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.