Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.47 |
| ▸ | TFEB | P19484 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2317111 | 1.00 | KMT2A (0.53) | KMT2AMEN1PTGDR2NFE2L2TFEB | |
| SCHEMBL2342765 | 0.87 | PTGDR2 (0.68) | KMT2AMEN1PTGDR2SMN1; SMN2MAPT | |
| SCHEMBL3312018 | 0.84 | MEN1 (0.51) | KMT2AMEN1PTGDR2NFE2L2TFEB | |
| SCHEMBL23188916 | 0.84 | MEN1 (0.51) | KMT2AMEN1PTGDR2NFE2L2TFEB | |
| SCHEMBL1287954 | 0.83 | PTGDR2 (0.72) | KMT2AMEN1PTGDR2SMN1; SMN2MAPT | |
| SCHEMBL20165421 | 0.83 | L3MBTL1 (0.55) | KMT2AMEN1PTGDR2SMN1; SMN2MAPT | |
| SCHEMBL20165417 | 0.83 | L3MBTL1 (0.55) | KMT2AMEN1PTGDR2SMN1; SMN2MAPT | |
| SCHEMBL17863711 | 0.81 | PTGDR2 (0.51) | KMT2AMEN1PTGDR2NFE2L2TFEB | |
| SCHEMBL16382639 | 0.80 | MEN1 (0.48) | KMT2AMEN1PTGDR2NFE2L2TFEB | |
| SCHEMBL2955119 | 0.80 | KMT2A (0.62) | KMT2APTGDR2SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066443-B1 | NOVEL METATHESIS CATALYSTS | UMICORE AG & CO KG (DE) | 2017-04-05 | — | — | EP | disclosed |
| EP-2066443-B1 | NOVEL METATHESIS CATALYSTS | UMICORE AG & CO KG (DE) | 2017-04-05 | — | — | EP | disclosed |
| US-9562116-B2 | Method for preparation of ruthenium-based metathesis catalysts with chelating alkylidene ligands | UMICORE AG & CO. KG (DE) | 2017-02-07 | — | — | US | disclosed |
| US-9562116-B2 | Method for preparation of ruthenium-based metathesis catalysts with chelating alkylidene ligands | UMICORE AG & CO. KG (DE) | 2017-02-07 | — | — | US | disclosed |
| US-20140371462-A1 | METHOD FOR PREPARATION OF RUTHENIUM-BASED METATHESIS CATALYSTS WITH CHELATING ALKYLIDENE LIGANDS | UMICORE AG & CO KG (DE) | 2014-12-18 | — | — | US | disclosed |
| US-20140371462-A1 | METHOD FOR PREPARATION OF RUTHENIUM-BASED METATHESIS CATALYSTS WITH CHELATING ALKYLIDENE LIGANDS | UMICORE AG & CO KG (DE) | 2014-12-18 | — | — | US | disclosed |
| US-8846938-B2 | Method for preparation of ruthenium-based metathesis catalysts with chelating alkylidene ligands | UMICORE AG & CO. KG (DE) | 2014-09-30 | — | — | US | disclosed |
| US-8846938-B2 | Method for preparation of ruthenium-based metathesis catalysts with chelating alkylidene ligands | UMICORE AG & CO. KG (DE) | 2014-09-30 | — | — | US | disclosed |
| EP-2255877-B1 | Method for preparation of ruthenium-based metathesis catalysts with chelating alkylidene ligands | UMICORE AG & CO KG (DE) | 2014-09-24 | — | — | EP | disclosed |
| US-8536344-B2 | Metathesis catalysts | UMICORE AG & CO. KG (DE) | 2013-09-17 | — | — | US | disclosed |
| US-20120101279-A1 | METHOD FOR PREPARATION OF RUTHENIUM-BASED METATHESIS CATALYSTS WITH CHELATING ALKYLIDENE LIGANDS | UMICORE AG & CO. KG (DE) | 2012-04-26 | — | — | US | disclosed |
| US-20120101279-A1 | METHOD FOR PREPARATION OF RUTHENIUM-BASED METATHESIS CATALYSTS WITH CHELATING ALKYLIDENE LIGANDS | UMICORE AG & CO. KG (DE) | 2012-04-26 | — | — | US | disclosed |
| EP-2255877-A1 | Method for preparation of ruthenium-based metathesis catalysts with chelating alkylidene ligands | Umicore AG & Co. KG (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2010127829-A1 | METHOD FOR PREPARATION OF RUTHENIUM-BASED METATHESIS CATALYSTS WITH CHELATING ALKYLIDENE LIGANDS | UMICORE AG & CO. KG (DE) | 2010-11-11 | — | — | WO | disclosed |
| US-20100113795-A1 | NOVEL METATHESIS CATALYSTS | UMICORE AG & CO. KG (DE) | 2010-05-06 | — | — | US | disclosed |
| US-20100113795-A1 | NOVEL METATHESIS CATALYSTS | UMICORE AG & CO. KG (DE) | 2010-05-06 | — | — | US | disclosed |
| US-20100113795-A1 | NOVEL METATHESIS CATALYSTS | UMICORE AG & CO. KG (DE) | 2010-05-06 | — | — | US | disclosed |
| EP-2066443-A1 | NOVEL METATHESIS CATALYSTS | Umicore AG & Co. KG (DE) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008034552-A1 | NOVEL METATHESIS CATALYSTS | UMICORE AG & CO. KG (DE) | 2008-03-27 | — | — | WO | disclosed |
| WO-2008034552-A1 | NOVEL METATHESIS CATALYSTS | UMICORE AG & CO. KG (DE) | 2008-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113795-A1 | NOVEL METATHESIS CATALYSTS | CYP1B1, CYP51A1, CYP1A1 | KMT2A 2895/4885MEN1 13/4885PTGDR2 3501/4885 |
| US-20120101279-A1 | METHOD FOR PREPARATION OF RUTHENIUM-BASED METATHESIS CATALYSTS WITH CHELATING ALKYLIDENE LIGANDS | HMOX2, TIMCC, HPD | KMT2A 572/4885MEN1 1992/4885PTGDR2 448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.