SCHEMBL20165853

SCHEMBL20165853

Cc1ccc2c(c1C)Cc1c-2[nH]c2ccccc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 17/20 0.59
CA2 P00918 17/20 0.59
CA4 P22748 17/20 0.59
CA6 P23280 17/20 0.59
AURKA O14965 1/20 0.50
AURKB Q96GD4 1/20 0.50
CCNT1 O60563 1/20 0.47
CCNB2 O95067 1/20 0.47
CDK1 P06493 1/20 0.47
CCNB1 P14635 1/20 0.47
CCNA2 P20248 1/20 0.47
CDK2 P24941 1/20 0.47
GSK3B P49841 1/20 0.47
CDK9 P50750 1/20 0.47
CCNA1 P78396 1/20 0.47
CDK5 Q00535 1/20 0.47
CDK5R1 Q15078 1/20 0.47
SIRT2 Q8IXJ6 1/20 0.47
CCNB3 Q8WWL7 1/20 0.47
SIRT1 Q96EB6 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17963741 0.82 CA1 (0.67) CA1CA2CA4CA6AURKA
SCHEMBL9528165 0.79 CA1 (0.57) CA1CA2CA4CA6AURKA
SCHEMBL8946555 0.77 CA1 (0.60) CA1CA2CA4CA6AURKA
SCHEMBL2787280 0.74 KIF11 (0.47) CA1CA2CA4CA6
SCHEMBL8523044 0.72 CA1 (0.67) CA1CA2CA4CA6CCNT1
Hydrochloric Acid SCHEMBL7736370 0.71 CA1 (0.65) CA1CA2CA4CA6CCNT1
Hydrochloric Acid SCHEMBL6481074 0.71 CA1 (0.65) CA1CA2CA4CA6CCNT1
Hydrochloric Acid SCHEMBL7723658 0.71 CA1 (0.65) CA1CA2CA4CA6CCNT1
Hydrochloric Acid SCHEMBL4629488 0.71 CA1 (0.60) CA1CA2CA4CA6AURKA
SCHEMBL2298597 0.70 CA1 (1.00) CA1CA2CA4CA6CCNT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018093085-A1 POLYETHYLENE RESIN EXHIBITING EXCELLENT IMPACT STRENGTH 주식회사 엘지화학 2018-05-24 WO disclosed