Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MC4R | P32245 | 2/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 6/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 6/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 6/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 6/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 6/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 6/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20168793 | 0.91 | MEN1 (0.34) | MGLLRXRANR1H2MEN1KMT2A | |
| SCHEMBL29531297 | 0.86 | MGLL (0.47) | MGLLRXRANR1H2MEN1KMT2A | |
| SCHEMBL20168756 | 0.84 | MGLL (0.43) | MGLL | |
| SCHEMBL20168794 | 0.83 | MGLL (0.44) | MGLL | |
| SCHEMBL20136986 | 0.81 | MGLL (0.62) | MGLL | |
| SCHEMBL29531245 | 0.81 | MGLL (0.62) | MGLL | |
| SCHEMBL20166773 | 0.81 | MGLL (0.46) | MGLL | |
| SCHEMBL25250466 | 0.80 | MGLL (0.44) | MGLL | |
| SCHEMBL20168796 | 0.79 | MGLL (0.41) | MGLLRXRANR1H2MEN1KMT2A | |
| SCHEMBL20137383 | 0.78 | MGLL (0.52) | MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541821-A1 | MAGL INHIBITORS | Abide Therapeutics, Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| EP-3541822-A1 | MAGL INHIBITORS | Abide Therapeutics, Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018093946-A1 | MAGL INHIBITORS | ABIDE THERAPEUTICS, INC. (US) | 2018-05-24 | — | — | WO | disclosed |
| WO-2018093947-A1 | MAGL INHIBITORS | ABIDE THERAPEUTICS, INC. (US) | 2018-05-24 | — | — | WO | disclosed |
| US-9249149-B2 | Deuterated derivatives of ruxolitinib | CONCERT PHARMACEUTICALS, INC. (US) | 2016-02-02 | — | — | US | disclosed |