Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30140381 | 1.00 | IDO1 (0.44) | IDO1EP300KAT8ALDH1A1CYP3A4 | |
| SCHEMBL27677397 | 0.83 | IDO1 (0.44) | IDO1EP300KAT8ALDH1A1CYP3A4 | |
| SCHEMBL1429875 | 0.80 | IDO1 (0.48) | IDO1EP300KAT8ALDH1A1CYP3A4 | |
| SCHEMBL17276035 | 0.78 | MAPT (0.47) | IDO1EP300KAT8ALDH1A1CYP3A4 | |
| SCHEMBL4300328 | 0.78 | HTR2A (0.41) | ALDH1A1PTGS1MAPK1HTTRAB9A | |
| SCHEMBL30829726 | 0.78 | HTR2A (0.41) | ALDH1A1PTGS1MAPK1HTTRAB9A | |
| SCHEMBL28133430 | 0.78 | IDO1 (0.47) | IDO1EP300KAT8ALDH1A1CYP3A4 | |
| SCHEMBL13578451 | 0.77 | TUBB1 (0.44) | ALDH1A1CYP3A4L3MBTL1PTGS1APP | |
| SCHEMBL1766161 | 0.77 | IDO1 (0.45) | IDO1EP300KAT8ALDH1A1CYP3A4 | |
| SCHEMBL27471733 | 0.77 | IDO1 (0.45) | IDO1EP300KAT8ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023061294-A1 | NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 再鼎医药(上海)有限公司 | 2023-04-20 | — | — | WO | disclosed |
| WO-2023061294-A1 | NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 再鼎医药(上海)有限公司 | 2023-04-20 | — | — | WO | disclosed |
| US-20200317642-A1 | AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND DERIVATIVES THEREOF | Epizyme, Inc. | 2020-10-08 | — | — | US | disclosed |
| US-10781208-B2 | 5,6-dihydro-11H-indolo[2,3-B]quinolin-11-ones as alk inhibitors | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-09-22 | — | — | US | disclosed |
| US-10781208-B2 | 5,6-dihydro-11H-indolo[2,3-B]quinolin-11-ones as alk inhibitors | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-09-22 | — | — | US | disclosed |
| CN-111343988-A | Amine-substituted heterocyclic compounds and derivatives thereof as EHMT2 inhibitors | EPIZYME股份有限公司 | 2020-06-26 | — | — | CN | disclosed |
| US-20190315741-A1 | 5,6-DIHYDRO-11H-INDOLO[2,3-B]QUINOLIN-11-ONES AS ALK INHIBITORS | UNIV MICHIGAN REGENTS (US) | 2019-10-17 | — | — | US | disclosed |
| US-20190315741-A1 | 5,6-DIHYDRO-11H-INDOLO[2,3-B]QUINOLIN-11-ONES AS ALK INHIBITORS | UNIV MICHIGAN REGENTS (US) | 2019-10-17 | — | — | US | disclosed |
| EP-3541816-A1 | 5,6-DIHYDRO-11H-INDOLO[2,3-B]QUINOLIN-11-ONES AS ALK INHIBITORS | The Regents of The University of Michigan (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018094134-A1 | 5,6-DIHYDRO-11H-INDOLO[2,3-B]QUINOLIN-11-ONES AS ALK INHIBITORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-05-24 | — | — | WO | disclosed |
| WO-2018094134-A1 | 5,6-DIHYDRO-11H-INDOLO[2,3-B]QUINOLIN-11-ONES AS ALK INHIBITORS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315741-A1 | 5,6-DIHYDRO-11H-INDOLO[2,3-B]QUINOLIN-11-ONES AS ALK INHIBITORS | ALK, KRAS, ABL1 | IDO1 481/4885EP300 1488/4885KAT8 4427/4885 |
| US-20200317642-A1 | AMINE-SUBSTITUTED HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS AND DERIVATIVES THEREOF | HNMT, EHMT2, SHMT2 | IDO1 824/4885EP300 46/4885KAT8 785/4885 |
| US-10781208-B2 | 5,6-dihydro-11H-indolo[2,3-B]quinolin-11-ones as alk inhibitors | ALK, KRAS, ABL1 | IDO1 490/4885EP300 1530/4885KAT8 4547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.