Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.35 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20182174 | 0.81 | DRD2 (0.40) | DRD2DRD4DRD3SCN9ASCN5A | |
| SCHEMBL20162937 | 0.81 | DRD2 (0.40) | DRD2DRD4DRD3SCN9ASCN5A | |
| SCHEMBL30037541 | 0.81 | DRD2 (0.40) | DRD2DRD4DRD3SCN9ASCN5A | |
| SCHEMBL3541053 | 0.78 | NOTUM (0.58) | FGFR1FGFR4SCN9ASCN5ANOTUM | |
| SCHEMBL29246282 | 0.75 | FGFR1 (0.56) | FGFR1FGFR4SCN9ASCN5ANOTUM | |
| SCHEMBL30910343 | 0.75 | FGFR1 (0.56) | FGFR1FGFR4SCN9ASCN5ANOTUM | |
| SCHEMBL31632925 | 0.73 | PI4KA (0.47) | FGFR1FGFR4KDM4EKMT2ATP53 | |
| SCHEMBL31632948 | 0.72 | FGFR1 (0.53) | FGFR1FGFR4SCN9ASCN5ANOTUM | |
| SCHEMBL30910346 | 0.72 | FGFR1 (0.59) | FGFR1FGFR4SCN9ASCN5ANOTUM | |
| SCHEMBL29246436 | 0.72 | FGFR1 (0.59) | FGFR1FGFR4SCN9ASCN5ANOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541390-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | Cystic Fibrosis Foundation Therapeutics Inc. (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |