Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 3/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162937 | 0.87 | DRD2 (0.40) | DRD2DRD4DRD3KMT2AMEN1 | |
| SCHEMBL30037541 | 0.87 | DRD2 (0.40) | DRD2DRD4DRD3KMT2AMEN1 | |
| SCHEMBL20182201 | 0.81 | NOTUM (0.48) | CFTRKCNH2GRIN2B | |
| SCHEMBL20168137 | 0.81 | FGFR1 (0.46) | DRD2DRD4DRD3KMT2AMEN1 | |
| SCHEMBL20181874 | 0.77 | CFTR (0.41) | KMT2AMEN1NR2F2CFTRDYRK1B | |
| SCHEMBL20162696 | 0.77 | CFTR (0.44) | DRD2DRD4DRD3KMT2AMEN1 | |
| SCHEMBL20162900 | 0.76 | SRC (0.47) | CFTR | |
| SCHEMBL20162862 | 0.73 | RET (0.47) | DRD2DRD4DRD3KMT2AMEN1 | |
| SCHEMBL20181869 | 0.73 | MEN1 (0.36) | KMT2AMEN1NR2F2KCNH2SCN5A | |
| SCHEMBL30538103 | 0.71 | CFTR (0.55) | DRD2DRD4DRD3CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018094137-A1 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | CYSTIC FIBROSIS FOUNDATION THERAPEUTICS INC. (US) | 2018-05-24 | — | — | WO | disclosed |