Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 3/20 | 0.61 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.56 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | CTSS | P25774 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.54 |
| ▸ | SNCA | P37840 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30109352 | 1.00 | SPR (0.61) | SPRTRPV1NOTUMKDM4EALDH1A1 | |
| SCHEMBL20168557 | 1.00 | SPR (0.61) | SPRTRPV1NOTUMKDM4EALDH1A1 | |
| SCHEMBL20182262 | 0.86 | TRPV1 (0.73) | SPRTRPV1NOTUMKDM4EALDH1A1 | |
| SCHEMBL23535627 | 0.85 | SPR (0.69) | SPRTRPV1NOTUMKDM4EALDH1A1 | |
| SCHEMBL20168183 | 0.85 | SPR (0.69) | SPRTRPV1NOTUMKDM4EALDH1A1 | |
| SCHEMBL23552961 | 0.83 | SPR (0.70) | SPRTRPV1NOTUMKDM4EALDH1A1 | |
| SCHEMBL23552681 | 0.81 | SPR (0.64) | SPRTRPV1NOTUMKDM4EALDH1A1 | |
| SCHEMBL21470293 | 0.80 | TRPV1 (0.70) | SPRTRPV1NOTUMKDM4EALDH1A1 | |
| SCHEMBL20182419 | 0.80 | TRPV1 (0.70) | SPRTRPV1NOTUMKDM4EALDH1A1 | |
| SCHEMBL20182380 | 0.79 | SPR (0.64) | SPRTRPV1NOTUMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12570606-B2 | Myeloperoxidase imaging agents | THE GENERAL HOSPITAL CORPORATION (US) | 2026-03-10 | — | — | US | disclosed |
| EP-3541431-B1 | MYELOPEROXIDASE IMAGING AGENTS | MASSACHUSETTS GEN HOSPITAL (US) | 2024-04-17 | — | — | EP | disclosed |
| CN-110177581-B | Myeloperoxidase imaging agents | 通用医疗公司 | 2023-01-03 | — | — | CN | disclosed |
| US-20220340524-A1 | Myeloperoxidase Imaging Agents | THE GENERAL HOSPITAL CORPORATION | 2022-10-27 | — | — | US | disclosed |
| US-11352326-B2 | Myeloperoxidase imaging agents | THE GENERAL HOSPITAL CORPORATION (US) | 2022-06-07 | — | — | US | disclosed |
| US-11352326-B2 | Myeloperoxidase imaging agents | THE GENERAL HOSPITAL CORPORATION (US) | 2022-06-07 | — | — | US | disclosed |
| US-20190315689-A1 | Myeloperoxidase Imaging Agents | THE GENERAL HOSPITAL CORPORATION | 2019-10-17 | — | — | US | disclosed |
| US-20190315689-A1 | Myeloperoxidase Imaging Agents | THE GENERAL HOSPITAL CORPORATION | 2019-10-17 | — | — | US | disclosed |
| EP-3541431-A1 | MYELOPEROXIDASE IMAGING AGENTS | The General Hospital Corporation (US) | 2019-09-25 | — | — | EP | disclosed |
| WO-2018094005-A1 | MYELOPEROXIDASE IMAGING AGENTS | THE GENERAL HOSPITAL CORPORATION (US) | 2018-05-24 | — | — | WO | disclosed |
| WO-2018094005-A1 | MYELOPEROXIDASE IMAGING AGENTS | THE GENERAL HOSPITAL CORPORATION (US) | 2018-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220340524-A1 | Myeloperoxidase Imaging Agents | MPO, CAT, EPX | SPR 360/4885TRPV1 2817/4885NOTUM 899/4885 |
| US-12570606-B2 | Myeloperoxidase imaging agents | MPO, CBR1, NOX1 | SPR 2313/4885TRPV1 2979/4885NOTUM 2157/4885 |
| US-20190315689-A1 | Myeloperoxidase Imaging Agents | MPO, CAT, EPX | SPR 242/4885TRPV1 3731/4885NOTUM 651/4885 |
| US-11352326-B2 | Myeloperoxidase imaging agents | MPO, CAT, EPX | SPR 242/4885TRPV1 3731/4885NOTUM 651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.