Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | STAT3 | P40763 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 3/20 | 0.48 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3788597 | 0.96 | HTT (0.56) | L3MBTL1HTTHRH3ALDH1A1KDM4E | |
| SCHEMBL9668347 | 0.87 | HTT (0.46) | L3MBTL1HTTACHEMCOLN3MEN1 | |
| SCHEMBL23310509 | 0.85 | KMT2A (0.58) | L3MBTL1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL16485862 | 0.84 | L3MBTL1 (0.51) | L3MBTL1HRH3ACHEMEN1KMT2A | |
| SCHEMBL3793071 | 0.83 | KMT2A (0.55) | HTTALDH1A1KDM4ESTAT3MEN1 | |
| SCHEMBL27952072 | 0.81 | GAA (0.50) | L3MBTL1HRH3ACHEMEN1KMT2A | |
| SCHEMBL27952027 | 0.81 | MAOB (0.53) | L3MBTL1HTTHRH3ALDH1A1MEN1 | |
| SCHEMBL3796336 | 0.80 | KMT2A (0.57) | HTTALDH1A1KDM4ESTAT3MEN1 | |
| SCHEMBL1640898 | 0.80 | HTT (0.76) | HTTALDH1A1KDM4ESTAT3 | |
| SCHEMBL6166995 | 0.79 | KMT2A (0.50) | L3MBTL1HRH3ACHEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102858767-A | Aminopyrimidines as SYK inhibitors | MERCK SHARP & DOHME | 2013-01-02 | — | — | CN | disclosed |
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |