Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31167233 | 0.90 | KMT2A (0.50) | KMT2AMEN1ACHEL3MBTL1ACACB | |
| SCHEMBL23310509 | 0.85 | KMT2A (0.58) | KMT2AMEN1L3MBTL1ACACBSMN1; SMN2 | |
| SCHEMBL3788597 | 0.83 | HTT (0.56) | KMT2AMEN1L3MBTL1ACACBHRH3 | |
| SCHEMBL27952027 | 0.82 | MAOB (0.53) | KMT2AMEN1L3MBTL1ACACBHRH3 | |
| SCHEMBL27952072 | 0.82 | GAA (0.50) | KMT2AMEN1ACHEL3MBTL1ACACB | |
| SCHEMBL3786400 | 0.80 | L3MBTL1 (0.53) | KMT2AMEN1ACHEL3MBTL1SMN1; SMN2 | |
| SCHEMBL2016911 | 0.79 | L3MBTL1 (0.55) | KMT2AMEN1ACHEL3MBTL1HRH3 | |
| SCHEMBL16485862 | 0.79 | L3MBTL1 (0.51) | KMT2AMEN1ACHEL3MBTL1ACACB | |
| SCHEMBL31166947 | 0.79 | HDAC6 (0.51) | KMT2AMEN1L3MBTL1ACACBSMN1; SMN2 | |
| SCHEMBL28159795 | 0.79 | ADRA1D (0.49) | KMT2AMEN1SMN1; SMN2ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558602-A2 | 2-PYRROLIDONES AS EP4 RECEPTOR AGONISTS | MERCK FROSST CANADA INC. (CA) | 2005-08-03 | — | — | EP | disclosed |
| EP-1513589-A1 | 1,5-DISUBSTITUTED PYRROLID-2-ONE DERIVATIVES FOR USE AS EP4 RECEPTOR AGONISTS IN THE TREATMENT OF EYE DISEASES SUCH AS GLAUCOMA | MERCK FROSST CANADA INC. (CA) | 2005-03-16 | — | — | EP | disclosed |
| WO-2004037786-A2 | 2-PYRROLIDONES AS EP4 RECEPTOR AGONISTS | MERCK FROSST CANADA & CO. (CA) | 2004-05-06 | — | — | WO | disclosed |
| WO-2003103772-A1 | 1,5-DISTRIBUTED PYRROLID-2-ONE DERIVATIVES FOR USE AS EP4 RECEPTOR AGONISTS IN THE TEATMENT OF EYE DISEASES SUCH AS GLAUCOMA | MERCK FROSST CANADA & CO. (CA) | 2003-12-18 | — | — | WO | disclosed |