SCHEMBL20169131

SCHEMBL20169131

Cc1ccc(-c2ccc3c(c2)/C(=C(/C#N)C(F)(F)F)c2ccc4c(c2-3)-c2ccc(-c3ccc(C(F)(F)F)cc3)cc2/C4=C(/C#N)C(F)(F)F)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.40
KIF11 P52732 6/20 0.37
KDM1A O60341 1/20 0.37
PDK2 Q15119 1/20 0.34
XDH P47989 1/20 0.33
MGAM O43451 1/20 0.33
GAA P10253 1/20 0.33
SI P14410 1/20 0.33
MGAM2 Q2M2H8 1/20 0.33
PSEN1 P49768 1/20 0.33
PSEN2 P49810 1/20 0.33
APH1B Q8WW43 1/20 0.33
NCSTN Q92542 1/20 0.33
APH1A Q96BI3 1/20 0.33
PSENEN Q9NZ42 1/20 0.33
PTPN5 P54829 1/20 0.33
CTSS P25774 1/20 0.32
CTSK P43235 1/20 0.32
APP P05067 1/20 0.32
TDP2 O95551 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12149305 0.94 AR (0.36) ARKIF11KDM1APDK2XDH
SCHEMBL15779891 0.94 KIF11 (0.41) ARKIF11XDHPSEN1PSEN2
SCHEMBL12149302 0.88 AR (0.42) ARKIF11KDM1APDK2XDH
SCHEMBL16433959 0.86 KIF11 (0.35) KIF11PSEN1PSEN2APH1BNCSTN
SCHEMBL12148668 0.82 AR (0.38) ARKIF11KDM1APDK2XDH
SCHEMBL15779899 0.80 KIF11 (0.44) ARKIF11PDK2GAAPSEN1
SCHEMBL12148672 0.80 AR (0.34) ARKIF11KDM1AXDH
SCHEMBL23940013 0.79
SCHEMBL12148949 0.79 AR (0.43) ARKIF11KDM1APDK2XDH
SCHEMBL12117578 0.79 AR (0.43) ARKIF11KDM1APDK2XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11575087-B1 Organic electroluminescence device, light emitting device, organic electroluminescence display device and electronic device IDEMITSU KOSAN CO., LTD. (JP) 2023-02-07 US disclosed
US-10411212-B2 Organic electroluminescent element IDEMITSU KOSAN CO., LTD. (JP) 2019-09-10 US disclosed
US-9978975-B2 Organic electroluminescence device JOLED INC (JP) 2018-05-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10411212-B2 Organic electroluminescent element L1CAM, NES, EML4 AR 2551/4885KIF11 2734/4885KDM1A 2530/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.