Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE6D | O43924 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE6A | P16499 | 1/20 | 0.35 |
| ▸ | PDE6G | P18545 | 1/20 | 0.35 |
| ▸ | PDE6B | P35913 | 1/20 | 0.35 |
| ▸ | PDE6C | P51160 | 1/20 | 0.35 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 3/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL867544 | 0.62 | PDE5A (0.43) | PDE6DPDE5APDE6APDE6GPDE6B | |
| SCHEMBL867319 | 0.61 | KMT2A (0.48) | PDE6DPDE5APDE6APDE6GPDE6B | |
| SCHEMBL250976 | 0.61 | TRPV4 (0.49) | AR | |
| SCHEMBL10251964 | 0.58 | PGR (0.37) | — | |
| SCHEMBL21081646 | 0.57 | AR (0.44) | AR | |
| SCHEMBL27707424 | 0.57 | HPGDS (0.60) | AR | |
| SCHEMBL31380328 | 0.56 | LRRK2 (0.39) | LRRK2AR | |
| SCHEMBL19851326 | 0.56 | AR (0.44) | LRRK2AR | |
| SCHEMBL15483059 | 0.56 | TRPV4 (0.39) | LRRK2AR | |
| SCHEMBL23502944 | 0.56 | TRPV4 (0.44) | LRRK2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9974782-B2 | Phosphodiesterase inhibitors and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-05-22 | — | — | US | disclosed |