Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19965685 | 0.83 | AGBL2 (0.32) | — | |
| SCHEMBL469180 | 0.83 | AGBL2 (0.32) | — | |
| SCHEMBL23365996 | 0.81 | NOS3 (0.42) | CCR1CCR5CCR8NOS3NOS1 | |
| SCHEMBL12041152 | 0.80 | CCR1 (0.35) | CCR1CCR5CCR8NOS3NOS1 | |
| SCHEMBL22630751 | 0.80 | SHBG (0.30) | — | |
| SCHEMBL20098097 | 0.79 | TAAR1 (0.37) | — | |
| SCHEMBL22919211 | 0.76 | CCR1 (0.35) | CCR1CCR5CCR8NOS3NOS1 | |
| SCHEMBL25150708 | 0.74 | TSHR (0.33) | CCR1CCR5CCR8NOS3NOS1 | |
| SCHEMBL18731449 | 0.73 | GCK (0.35) | — | |
| SCHEMBL21736826 | 0.69 | NOS3 (0.37) | CCR1CCR5CCR8NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9975896-B2 | Inhibitors of transcription factors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-22 | — | — | US | disclosed |