Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.57 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2010164 | 0.87 | HCRTR1 (0.57) | HCRTR1HCRTR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2012574 | 0.86 | HCRTR1 (0.60) | HCRTR1HCRTR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2012853 | 0.85 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9AMAPT | |
| SCHEMBL2015844 | 0.84 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9AKMT2A | |
| SCHEMBL2012888 | 0.84 | HCRTR1 (0.62) | HCRTR1HCRTR2NPC1RAB9AKMT2A | |
| SCHEMBL2010621 | 0.83 | HCRTR1 (0.63) | HCRTR1HCRTR2NPC1RAB9AKMT2A | |
| SCHEMBL2013232 | 0.83 | HCRTR1 (0.63) | HCRTR1HCRTR2NPC1RAB9A | |
| SCHEMBL2054318 | 0.83 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9AMAPT | |
| SCHEMBL2011240 | 0.83 | HCRTR1 (0.58) | HCRTR1HCRTR2NPC1RAB9AMAPT | |
| SCHEMBL2014998 | 0.83 | HCRTR1 (0.59) | HCRTR1HCRTR2NPC1RAB9APADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | claimed |
| WO-2011073316-A1 | 4-ARYL-BUTANE-1,3-DIAMIDES | NOVARTIS AG (CH) | 2011-06-23 | — | — | WO | disclosed |