SCHEMBL2010164

SCHEMBL2010164

Cc1nc2cccc(C(=O)N(C)C(CCNC(=O)c3cccn3C)Cc3ccccc3)c2o1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.57
HCRTR2 O43614 2/20 0.57
KMT2A Q03164 3/20 0.49
ESR1 P03372 1/20 0.49
MAPT P10636 1/20 0.49
MAPK10 P53779 1/20 0.49
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
ALDH1A1 P00352 3/20 0.38
KDM4E B2RXH2 1/20 0.38
PADI4 Q9UM07 3/20 0.37
MEN1 O00255 2/20 0.36
UBE2N P61088 1/20 0.36
MTNR1A P48039 1/20 0.35
MTNR1B P49286 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2017043 0.87 HCRTR1 (0.57) HCRTR1HCRTR2KMT2AESR1MAPT
SCHEMBL2016442 0.86 HCRTR1 (0.60) HCRTR1HCRTR2MAPTNPC1RAB9A
SCHEMBL2017894 0.84 HCRTR1 (0.59) HCRTR1HCRTR2KMT2ANPC1RAB9A
SCHEMBL2052571 0.84 HCRTR1 (0.59) HCRTR1HCRTR2KMT2ANPC1RAB9A
SCHEMBL2012487 0.84 HCRTR1 (0.61) HCRTR1HCRTR2KMT2ANPC1RAB9A
SCHEMBL2010621 0.83 HCRTR1 (0.63) HCRTR1HCRTR2KMT2ANPC1RAB9A
SCHEMBL2013232 0.83 HCRTR1 (0.63) HCRTR1HCRTR2NPC1RAB9ACYP3A4
SCHEMBL2012651 0.83 HCRTR1 (0.59) HCRTR1HCRTR2KMT2ANPC1RAB9A
SCHEMBL2017423 0.83 HCRTR1 (0.62) HCRTR1HCRTR2MAPTNPC1RAB9A
SCHEMBL2012853 0.82 HCRTR1 (0.59) HCRTR1HCRTR2MAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO claimed
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO disclosed