SCHEMBL20170447

SCHEMBL20170447

CCCC(CC)C(=O)OC1CCCCCCC1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 2/20 0.53
CHRM3 P20309 2/20 0.53
ADRA1A P35348 2/20 0.53
CHRM2 P08172 1/20 0.53
CHRNA4 P43681 1/20 0.53
HTR3A P46098 1/20 0.53
KCNH2 Q12809 1/20 0.53
SMN1; SMN2 Q16637 2/20 0.51
NAAA Q02083 2/20 0.46
EPHX1 P07099 2/20 0.46
CYP19A1 P11511 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.38
HTT P42858 2/20 0.38
CYP2C19 P33261 1/20 0.37
AKR1A1 P14550 1/20 0.36
HTR2A P28223 1/20 0.36
HTR2C P28335 1/20 0.36
HRH1 P35367 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20170459 1.00 CHRM1 (0.53) CHRM1CHRM3ADRA1ACHRM2CHRNA4
SCHEMBL7224472 1.00 CHRM1 (0.53) CHRM1CHRM3ADRA1ACHRM2CHRNA4
SCHEMBL19115356 0.98 CHRM1 (0.54) CHRM1CHRM3ADRA1ACHRM2CHRNA4
SCHEMBL7217444 0.93 CHRM1 (0.59) CHRM1CHRM3ADRA1ACHRM2CHRNA4
SCHEMBL3908224 0.90 CA2 (0.54) CHRM1CHRM3ADRA1ACHRM2CHRNA4
SCHEMBL5827222 0.89 EPHX1 (0.52) CHRM1CHRM3ADRA1ACHRM2CHRNA4
Ammonia Solution, Strong SCHEMBL11651733 0.89 CA2 (0.53) CHRM1CHRM3ADRA1ACHRM2CHRNA4
SCHEMBL7223238 0.87 NAAA (0.56) CHRM1CHRM3ADRA1ACHRM2CHRNA4
SCHEMBL14875486 0.87 EPHX1 (0.48) CHRM1CHRM3ADRA1ACHRM2CHRNA4
SCHEMBL22086821 0.86 EPHX1 (0.42) CHRM1CHRM3ADRA1ACHRM2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3068391-B1 ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG MERCK SHARP & DOHME (US) 2018-05-23 EP disclosed