Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170709 | 0.90 | OPRM1 (0.51) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL12091233 | 0.89 | OPRM1 (0.56) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170792 | 0.88 | OPRM1 (0.50) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170757 | 0.88 | OPRD1 (0.54) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170677 | 0.88 | OPRM1 (0.50) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL16509912 | 0.86 | OPRM1 (0.54) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL10072363 | 0.81 | OPRM1 (0.59) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL16131234 | 0.78 | OPRM1 (0.55) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL14852726 | 0.78 | OPRM1 (0.55) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170694 | 0.77 | OPRM1 (0.45) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |