Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170776 | 1.00 | OPRM1 (0.45) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170763 | 1.00 | OPRM1 (0.45) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL12091233 | 0.88 | OPRM1 (0.56) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170679 | 0.87 | OPRD1 (0.43) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170721 | 0.87 | OPRD1 (0.43) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170611 | 0.79 | OPRM1 (0.41) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170755 | 0.79 | OPRM1 (0.41) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170764 | 0.79 | OPRM1 (0.41) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL18162960 | 0.78 | OPRM1 (0.46) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170649 | 0.77 | OPRM1 (0.54) | OPRM1OPRD1OPRK1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |