Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 14/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170880 | 0.92 | HCRTR1 (0.45) | HCRTR1HTR1A | |
| SCHEMBL20170799 | 0.81 | HCRTR1 (0.47) | HCRTR1HTR1A | |
| SCHEMBL20170650 | 0.81 | HCRTR1 (0.44) | HCRTR1HTR1A | |
| SCHEMBL20852459 | 0.79 | HTR1A (0.41) | HCRTR1HTR1A | |
| SCHEMBL10223933 | 0.75 | HCRTR1 (0.45) | HCRTR1HTR1A | |
| SCHEMBL20852445 | 0.72 | HTR1A (0.35) | HTR1A | |
| SCHEMBL20170738 | 0.68 | HTR1A (0.40) | HCRTR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL18473435 | 0.67 | HCRTR1 (0.42) | HCRTR1HTR1A | |
| SCHEMBL13972295 | 0.66 | HCRTR1 (0.41) | HCRTR1HTR1ADRD2DRD4DRD3 | |
| SCHEMBL18473438 | 0.66 | HCRTR1 (0.41) | HCRTR1HTR1ADRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |