Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 5/20 | 0.47 |
| ▸ | HTR1A | P08908 | 8/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170880 | 0.82 | HCRTR1 (0.45) | HCRTR1HTR1A | |
| SCHEMBL20170731 | 0.81 | HCRTR1 (0.43) | HCRTR1HTR1A | |
| SCHEMBL20170753 | 0.74 | GABRA1 (0.39) | HCRTR1GABRA1GABRB2NQO2MTNR1A | |
| SCHEMBL20170650 | 0.71 | HCRTR1 (0.44) | HCRTR1HTR1A | |
| SCHEMBL18473438 | 0.64 | HCRTR1 (0.41) | HCRTR1HTR1AOPRK1 | |
| SCHEMBL13972295 | 0.64 | HCRTR1 (0.41) | HCRTR1HTR1AOPRK1 | |
| SCHEMBL13972294 | 0.64 | HCRTR1 (0.41) | HCRTR1HTR1AOPRK1 | |
| SCHEMBL20170820 | 0.64 | HCRTR1 (0.46) | HCRTR1OPRK1 | |
| SCHEMBL20170592 | 0.63 | MTNR1A (0.40) | HCRTR1NQO2MTNR1AMTNR1B | |
| SCHEMBL20170750 | 0.63 | OPRM1 (0.51) | GABRA1GABRB2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |