Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 14/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 13/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170601 | 0.89 | OPRM1 (0.39) | OPRD1SIGMAR1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL12944959 | 0.89 | OPRM1 (0.39) | OPRD1SIGMAR1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL20170597 | 0.84 | OPRD1 (0.43) | OPRD1SIGMAR1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL12944958 | 0.84 | OPRD1 (0.43) | OPRD1SIGMAR1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL20170782 | 0.82 | OPRD1 (0.44) | OPRD1SIGMAR1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL12944956 | 0.78 | OPRD1 (0.41) | OPRD1SIGMAR1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL17284766 | 0.78 | OPRD1 (0.51) | OPRD1SIGMAR1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL10223380 | 0.78 | OPRD1 (0.51) | OPRD1SIGMAR1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL12945098 | 0.78 | GAA (0.37) | OPRD1OPRM1OPRK1ALDH1A1CYP3A4 | |
| SCHEMBL20170708 | 0.73 | OPRM1 (0.42) | OPRD1SIGMAR1OPRM1OPRK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |