Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170840 | 0.81 | GAA (0.41) | GAAKDM4EMAPT | |
| SCHEMBL20170807 | 0.76 | GAA (0.48) | GAACYP3A4CYP2D6OPRD1OPRM1 | |
| SCHEMBL10222582 | 0.72 | GAA (0.66) | GAAKDM4ECYP3A4MAPTCYP2D6 | |
| SCHEMBL14768978 | 0.72 | GAA (0.66) | GAAKDM4ECYP3A4MAPTCYP2D6 | |
| SCHEMBL21091196 | 0.70 | GAA (0.61) | GAAKDM4ECYP3A4MAPTCYP2D6 | |
| SCHEMBL18878794 | 0.69 | GAA (0.68) | GAAKDM4ECYP3A4MAPTCYP2D6 | |
| SCHEMBL18994724 | 0.68 | GAA (0.67) | GAAKDM4ECYP3A4MAPTCYP2D6 | |
| SCHEMBL12717590 | 0.67 | GAA (1.00) | GAAKDM4ECYP3A4MAPTCYP2D6 | |
| SCHEMBL12960964 | 0.67 | GAA (1.00) | GAAKDM4ECYP3A4MAPTCYP2D6 | |
| SCHEMBL21148321 | 0.67 | GAA (1.00) | GAAKDM4ECYP3A4MAPTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |