Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ERN1 | O75460 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170784 | 0.81 | GAA (0.51) | GAAKDM4EMAPT | |
| SCHEMBL20170711 | 0.77 | GAA (0.39) | GAA | |
| SCHEMBL10222587 | 0.76 | GAA (0.39) | GAAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20170701 | 0.76 | GAA (0.39) | GAA | |
| SCHEMBL12945025 | 0.76 | GAA (0.38) | GAAERN1ALDH1A1KDM4ETSHR | |
| SCHEMBL12945027 | 0.76 | GAA (0.38) | GAA | |
| SCHEMBL20170666 | 0.72 | GAA (0.37) | GAAIGF1RALDH1A1MAPTHPGD | |
| SCHEMBL6123801 | 0.72 | GAA (0.46) | GAAIGF1RALDH1A1KDM4ETSHR | |
| SCHEMBL21202053 | 0.72 | GAA (0.43) | GAAIGF1RALDH1A1KDM4ETSHR | |
| SCHEMBL10033223 | 0.72 | GAA (0.46) | GAAIGF1RALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |