Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.32 |
| ▸ | PGR | P06401 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20170821 | 0.87 | GAA (0.36) | GAAOPRM1 | |
| SCHEMBL20170664 | 0.87 | GAA (0.36) | GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL20170718 | 0.81 | GAA (0.36) | GAAALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20170595 | 0.77 | GAA (0.36) | GAA | |
| SCHEMBL20170609 | 0.76 | NR3C1 (0.33) | GAANR3C1PGRAR | |
| SCHEMBL10222587 | 0.75 | GAA (0.39) | GAAHTR1AALDH1A1MAPTHPGD | |
| SCHEMBL20170707 | 0.75 | GAA (0.35) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL20170874 | 0.75 | ALOX5 (0.33) | GAANR3C1PGRARMEN1 | |
| SCHEMBL20170851 | 0.75 | GAA (0.34) | GAA | |
| SCHEMBL20170756 | 0.73 | TRPV1 (0.34) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2453895-B1 | (+) - MORPHINANS AS ANTAGONISTS OF TOLL-LIKE RECEPTOR 9 AND THERAPEUTIC USES THEREOF | MALLINCKRODT LLC (US) | 2018-05-23 | — | — | EP | disclosed |