SCHEMBL2017091

SCHEMBL2017091

NC(=O)C(CO)NCc1ccc(OCc2cccc(Cl)c2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.55
GID4 Q8IVV7 1/20 0.55
MAOA P21397 1/20 0.55
SCN9A Q15858 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2017087 1.00 MAOB (0.55) MAOBGID4MAOASCN9A
SCHEMBL31061697 1.00 MAOB (0.55) MAOBGID4MAOASCN9A
SCHEMBL2017824 1.00 MAOB (0.55) MAOBGID4MAOASCN9A
SCHEMBL7395180 0.87 MAOB (0.54) MAOBGID4MAOASCN9A
SCHEMBL3061396 0.87 MAOB (0.54) MAOBGID4MAOASCN9A
SCHEMBL2014885 0.86 MAOB (0.74) MAOBMAOASCN9A
SCHEMBL31060712 0.86 MAOB (0.74) MAOBMAOASCN9A
SCHEMBL963815 0.86 MAOB (0.74) MAOBMAOASCN9A
SCHEMBL8935315 0.86 ALOX5 (0.57) MAOBGID4MAOASCN9A
SCHEMBL7396992 0.86 BCHE (0.54)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102274517-A Methods for treatment of parkinson's disease 2011-12-14 CN claimed
EP-2070526-A1 \"Methods for treatment of Parkinson's disease\ Newron Pharmaceuticals S.p.A. (IT) 2009-06-17 EP claimed
US-20070093495-A1 Methods for treatment of parkinson's disease NEWRON PHARMACEUTICALS S.P.A. (IT) 2007-04-26 US claimed
CN-1771030-A Methods of treating Parkinson's disease NEWRON PHARMACEUTICALS INC (IT) 2006-05-10 CN claimed
EP-1613296-A2 METHODS FOR TREATMENT OF PARKINSON'S DISEASE Newron Pharmaceuticals S.p.A. (IT) 2006-01-11 EP claimed
WO-2004089353-A2 METHODS FOR TREATMENT OF PARKINSON'S DISEASE NEWRON PHARMACEUTICALS, S.P.A. (IT) 2004-10-21 WO claimed
US-9492410-B2 Methods for treatment of Parkinson's disease NEWRON PHARMACEUTICALS S.P.A. (IT) 2016-11-15 US disclosed
US-20150150833-A1 Methods For Treatment of Parkinson's Disease NEWRON PHARMACEUTICALS S.P.A. (IT) 2015-06-04 US disclosed
US-8901176-B2 Methods for treatment of Parkinson's disease NEWRON PHARMACEUTICALS, S.P.A. (IT) 2014-12-02 US disclosed
US-20130053368-A1 METHODS FOR TREATMENT OF PARKINSON'S DISEASE NEWRON PHARMACEUTICALS S.P.A (IT) 2013-02-28 US disclosed
US-8283380-B2 Methods for treatment of parkinson's disease NEWRON PHARMACEUTICALS S.P.A. (IT) 2012-10-09 US disclosed
CN-102274517-A Methods for treatment of parkinson's disease 2011-12-14 CN disclosed
US-20110160308-A1 Use of Monoamine Oxidase Inhibitors to Treat Outer Retina Disorders ALCON RESEARCH, LTD. (US) 2011-06-30 US disclosed
US-20070093495-A1 Methods for treatment of parkinson's disease NEWRON PHARMACEUTICALS S.P.A. (IT) 2007-04-26 US disclosed
CN-1771030-A Methods of treating Parkinson's disease NEWRON PHARMACEUTICALS INC (IT) 2006-05-10 CN disclosed
EP-1613296-A2 METHODS FOR TREATMENT OF PARKINSON'S DISEASE Newron Pharmaceuticals S.p.A. (IT) 2006-01-11 EP disclosed
WO-2004089353-A2 METHODS FOR TREATMENT OF PARKINSON'S DISEASE NEWRON PHARMACEUTICALS, S.P.A. (IT) 2004-10-21 WO disclosed
US-5391577-A Active on central nervous system; antiepileptic agents FARMITALIA CARLO ERBA S R L (IT) 1995-02-21 US disclosed
EP-0400495-B1 N-phenylalkyl substituted alpha-amino carboxamide derivatives and process for their preparation. ERBA CARLO SPA (IT) 1993-11-03 EP disclosed
US-5236957-A Antiepileptic agents FARMITALIA CARLO ERBA SRL (IT) 1993-08-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130053368-A1 METHODS FOR TREATMENT OF PARKINSON'S DISEASE MAOB, MAOA, SNCA MAOB 1/4885GID4 2385/4885MAOA 2/4885
US-20070093495-A1 Methods for treatment of parkinson's disease MAOB, MAOA, SNCA MAOB 1/4885GID4 2385/4885MAOA 2/4885
US-20110160308-A1 Use of Monoamine Oxidase Inhibitors to Treat Outer Retina Disorders MAOB, MAOA, ALDH1A2 MAOB 1/4885GID4 1295/4885MAOA 2/4885
US-20150150833-A1 Methods For Treatment of Parkinson's Disease MAOB, MAOA, SNCA MAOB 1/4885GID4 2385/4885MAOA 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.