Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.49 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14319657 | 0.86 | EGLN1 (0.56) | EGLN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1921935 | 0.83 | EGLN1 (0.70) | EGLN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1921244 | 0.80 | EGLN1 (0.61) | EGLN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL25003152 | 0.77 | MAP4K4 (0.52) | EGLN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4371717 | 0.77 | EGLN1 (0.61) | EGLN1EGLN3CTSACNR1 | |
| SCHEMBL14882746 | 0.75 | KDM4D (0.52) | EGLN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL24405095 | 0.74 | PSEN1 (0.36) | EGLN1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL18135104 | 0.74 | GAA (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL31301463 | 0.74 | MET (0.62) | METCNR1 | |
| SCHEMBL14308515 | 0.73 | EGLN1 (0.51) | EGLN1MMP13EGLN3KMOCTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357911-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-3323807-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | Akebia Therapeutics, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |