SCHEMBL31301463

SCHEMBL31301463

O=C(Nc1ccc(Cl)cc1)c1cc(-c2ccc(Cl)cc2)ccn1

nearest known ligand 0.62

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MET P08581 3/20 0.62
CNR1 P21554 5/20 0.58
KDR P35968 2/20 0.56
SMO Q99835 2/20 0.53
MAPK1 P28482 1/20 0.53
LMNA P02545 2/20 0.52
MAPT P10636 1/20 0.52
ABL1 P00519 1/20 0.51
CCNC P24863 1/20 0.51
CDK8 P49336 1/20 0.51
NPC1 O15118 2/20 0.50
RAB9A P51151 2/20 0.50
SMN1; SMN2 Q16637 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15901016 0.87 NPC1 (0.63) KDRMAPK1LMNAMAPTNPC1
SCHEMBL14882746 0.85 KDM4D (0.52) METCNR1
SCHEMBL18135104 0.84 GAA (0.56) METCNR1KDRRAB9ASMN1; SMN2
SCHEMBL25003152 0.84 MAP4K4 (0.52) METCNR1KDRLMNAMAPT
SCHEMBL29834818 0.83 KDR (0.67) METKDRMAPK1ABL1CCNC
SCHEMBL27173842 0.83 KDR (0.67) METKDRMAPK1ABL1CCNC
SCHEMBL27847068 0.82 CCNC (0.62) CNR1KDRSMOCCNCCDK8
SCHEMBL1937813 0.81 RAB9A (0.56) METCNR1KDRLMNAABL1
SCHEMBL1938750 0.80 GRM4 (0.55) CNR1KDRSMOMAPTCCNC
SCHEMBL1939830 0.80 KMO (0.58) METKDRSMOLMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4727549-A2 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS University of Georgia Research Foundation, Inc. (US) 2026-04-22 EP disclosed
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS UNIV GEORGIA (US) 2026-04-09 US disclosed
WO-2024258900-A2 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) 2024-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260097046-A1 PLASMODIUM FALCIPARUM BLOOD STAGE INHIBITORS SUB1, PFN1, HCCS MET 1552/4885CNR1 1129/4885KDR 1639/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.