Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 11/20 | 0.47 |
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 8/20 | 0.47 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | MPI | P34949 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | METAP2 | P50579 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.43 |
| ▸ | LMNA | P02545 | 9/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2018078 | 0.86 | MAPT (0.52) | HTTMAPTNPSR1RAB9AKMT2A | |
| SCHEMBL2016046 | 0.85 | SMO (0.49) | HTTMAPTNPSR1RAB9AKMT2A | |
| SCHEMBL2015402 | 0.84 | AKR1C3 (0.43) | HTTMAPTNPSR1RAB9AKMT2A | |
| SCHEMBL2012009 | 0.84 | MAPT (0.46) | HTTMAPTNPSR1RAB9AKMT2A | |
| SCHEMBL2012195 | 0.84 | ALDH1A1 (0.44) | HTTMAPTNPSR1RAB9AKMT2A | |
| SCHEMBL2014194 | 0.83 | L3MBTL1 (0.48) | HTTMAPTNPSR1RAB9AKMT2A | |
| SCHEMBL2016559 | 0.83 | IDE (0.45) | HTTMAPTNPSR1RAB9AKMT2A | |
| SCHEMBL2017181 | 0.82 | L3MBTL1 (0.44) | HTTMAPTNPSR1RAB9AKMT2A | |
| SCHEMBL2016546 | 0.82 | KDM4E (0.53) | HTTMAPTNPSR1RAB9AKMT2A | |
| SCHEMBL2011832 | 0.82 | L3MBTL1 (0.50) | HTTMAPTNPSR1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075630-A1 | SUBSTITUTED FUSED ARYL AND HETEROARYL DERIVATIVES AS PI3K INHIBITORS | INCYTE CORPORATION (US) | 2011-06-23 | — | — | WO | disclosed |