Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SLC29A1 | Q99808 | 3/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20171935 | 0.88 | MAPK1 (0.43) | LMNASMN1; SMN2NPSR1MAPK1HTT | |
| SCHEMBL20171912 | 0.81 | HTT (0.38) | LMNAMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL16212037 | 0.81 | CNR2 (0.56) | CNR2 | |
| SCHEMBL16211714 | 0.79 | CNR2 (0.54) | CNR2 | |
| SCHEMBL2229901 | 0.79 | NPY5R (0.43) | LMNAMEN1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL14071956 | 0.78 | NPY5R (0.46) | LMNAMEN1KMT2AMAPK1L3MBTL1 | |
| SCHEMBL20171876 | 0.76 | HTT (0.41) | LMNAALDH1A1SMN1; SMN2MAPK1HTT | |
| SCHEMBL14183741 | 0.76 | HTT (0.41) | LMNAALDH1A1SMN1; SMN2MAPK1HTT | |
| SCHEMBL8830247 | 0.76 | CHUK (0.48) | LMNAMAPK1HTTTP53ALOX15 | |
| SCHEMBL4513985 | 0.75 | TLR7 (0.47) | LMNAMEN1KMT2AALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2991987-B1 | PURINE DERIVATIVES AS CB2 RECEPTOR AGONISTS | HOFFMANN LA ROCHE (CH) | 2018-05-23 | — | — | EP | disclosed |