Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20171924 | 0.88 | LMNA (0.50) | MAPK1LMNANPSR1HTTSMN1; SMN2 | |
| SCHEMBL16211714 | 0.81 | CNR2 (0.54) | LRRK2 | |
| SCHEMBL14071958 | 0.81 | MAP2K7 (0.45) | MAPK1CHEK1PDPK1PAK1LMNA | |
| SCHEMBL8826341 | 0.78 | IKBKB (0.52) | MAPK1CHEK1PDPK1PAK1LRRK2 | |
| SCHEMBL30253959 | 0.78 | CHEK1 (0.44) | MAPK1CHEK1PDPK1PAK1LRRK2 | |
| SCHEMBL336113 | 0.78 | CHEK1 (0.44) | MAPK1CHEK1PDPK1PAK1LRRK2 | |
| SCHEMBL19414424 | 0.78 | CHEK1 (0.44) | MAPK1CHEK1PDPK1PAK1STAT3 | |
| SCHEMBL16212037 | 0.78 | CNR2 (0.56) | — | |
| SCHEMBL20171906 | 0.78 | CNR2 (0.44) | MAPK1CHEK1PDPK1PAK1LRRK2 | |
| SCHEMBL29804858 | 0.74 | CHEK1 (0.60) | MAPK1CHEK1PDPK1PAK1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2991987-B1 | PURINE DERIVATIVES AS CB2 RECEPTOR AGONISTS | HOFFMANN LA ROCHE (CH) | 2018-05-23 | — | — | EP | disclosed |