Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 12/20 | 0.43 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14071956 | 0.98 | NPY5R (0.46) | NPY5RMAP2K7MAPK1HSD17B10L3MBTL1 | |
| SCHEMBL14071958 | 0.86 | MAP2K7 (0.45) | NPY5RMAP2K7MAPK1HSD17B10LMNA | |
| SCHEMBL20171876 | 0.81 | HTT (0.41) | MAPK1HSD17B10HTTTP53LMNA | |
| SCHEMBL8830247 | 0.81 | CHUK (0.48) | MAP2K7MAPK1HTTTP53LMNA | |
| SCHEMBL14183741 | 0.81 | HTT (0.41) | MAPK1HSD17B10HTTTP53LMNA | |
| SCHEMBL20171912 | 0.80 | HTT (0.38) | MAPK1MEN1KMT2AHTTTP53 | |
| SCHEMBL14183739 | 0.79 | ADORA3 (0.42) | MAPK1HTTTP53LMNAALOX15 | |
| SCHEMBL8830437 | 0.79 | CHUK (0.50) | NPY5RMAP2K7MAPK1HTTTP53 | |
| SCHEMBL8826309 | 0.79 | CHUK (0.50) | NPY5RMAP2K7MAPK1HTTTP53 | |
| SCHEMBL20171924 | 0.79 | LMNA (0.50) | MAPK1L3MBTL1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977343-B2 | Adenine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-12 | — | — | US | disclosed |
| US-20100160352-A1 | ADENINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160352-A1 | ADENINE DERIVATIVES | HSP90AA1, TRAP1, HSP90AB1 | NPY5R 3302/4885MAP2K7 2926/4885MAPK1 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.