SCHEMBL20172116

SCHEMBL20172116

Nc1cccc2c1Oc1ccncc1N2c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.36
CYP17A1 P05093 1/20 0.36
CYP3A4 P08684 2/20 0.33
CYP2D6 P10635 2/20 0.33
CYP2C9 P11712 2/20 0.33
CYP2C19 P33261 2/20 0.33
HSPA1A P0DMV8 1/20 0.33
PABPC1 P11940 1/20 0.33
LMNA P02545 1/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
RPS6KA5 O75582 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
POLB P06746 1/20 0.31
ALDH1A1 P00352 2/20 0.31
EGFR P00533 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20172086 0.89 CYP1A2 (0.36) CYP1A2CYP17A1CYP3A4CYP2D6CYP2C9
SCHEMBL17489963 0.84 HSPA1A (0.39) HSPA1APABPC1ADRA2AADRA2BADRA2C
SCHEMBL17490040 0.82 CYP1A2 (0.34) CYP1A2CYP17A1CYP3A4CYP2D6CYP2C9
SCHEMBL20308279 0.81 ALDH1A1 (0.38) CYP1A2CYP17A1CYP3A4CYP2D6CYP2C9
SCHEMBL17490039 0.76 CDK8 (0.37) LMNARPS6KA5POLBALDH1A1FGFR1
SCHEMBL20172208 0.76 ADRA2A (0.35) HSPA1APABPC1LMNAADRA2AADRA2B
SCHEMBL20172216 0.75 ADRA2A (0.37) HSPA1APABPC1LMNAADRA2AADRA2B
SCHEMBL17489712 0.71 CA12 (0.36) CYP1A2CYP17A1CYP3A4CYP2D6CYP2C9
SCHEMBL20308277 0.71 ALDH1A1 (0.33) CYP1A2CYP17A1CA12CA1CA2
SCHEMBL20308278 0.70 CDK8 (0.37) CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3339395-B1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO LTD (KR) 2019-10-02 EP disclosed
EP-2980182-B1 CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME SAMSUNG ELECTRONICS CO LTD (KR) 2018-05-23 EP disclosed